2-(4-Fluorophenyl)-thiophene CAS 58861-48-6: A Guide to Specifications, Applications, and Bulk Purchasing

2-(4-Fluorophenyl)-thiophene, identified by CAS No. 58861-48-6, is an aromatic thiophene building block containing a thiophene ring connected to a para-fluorophenyl group. I position this material primarily as a research and synthesis intermediate for customers developing substituted heteroaromatic compounds, electronic-material candidates, and medicinal chemistry libraries. For bulk purchasing, the most important checks are chemical identity, assay and impurity profile, packaging, documentation, and dependable delivery rather than relying on a name alone. Maison Chemical can support buyers by reviewing their required quantity, specification, application, and destination before preparing a commercial quotation.

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Who This Guide Is For

This guide is intended for procurement teams, research chemists, process-development groups, and manufacturers evaluating 2-(4-Fluorophenyl)-thiophene CAS 58861-48-6. It is especially relevant when a buyer needs to move from laboratory screening to repeatable sourcing or larger-scale synthesis. The information is structured to help buyers define a practical specification before requesting samples or bulk pricing. It does not replace the supplier’s current specification, safety data sheet, certificate of analysis, or customer-specific qualification requirements.

Basic Concept and Chemical Context

2-(4-Fluorophenyl)-thiophene combines two useful structural features: a sulfur-containing thiophene heterocycle and a fluorinated aromatic ring. This conjugated framework can be incorporated into further synthetic steps where aromatic substitution, coupling, functional-group transformation, or structure-property exploration is required. The exact reaction suitability depends on the downstream chemistry, catalyst system, solvent, temperature, and impurity tolerance.

The para-fluoro substituent is chemically significant because fluorine can influence molecular polarity, electronic distribution, lipophilicity, and metabolic behavior in certain research compounds. However, the presence of fluorine does not by itself establish a pharmaceutical effect, biological activity, or commercial application. I therefore recommend treating this material as a defined chemical intermediate and evaluating its performance in the buyer’s own validated synthesis.

Specifications Buyers Should Review

Identity and Appearance

The starting point is confirmation that the supplied material corresponds to CAS No. 58861-48-6 and the intended chemical structure. Buyers should request the product name, CAS number, molecular structure, lot number, appearance, and analytical identification method. Depending on the batch and handling conditions, the physical form and color should be confirmed against the supplier’s current product specification rather than assumed from a general catalog description.

A suitable documentation package normally includes a certificate of analysis and a safety data sheet. For technical evaluation, buyers may also request representative analytical data such as chromatographic purity, proton or carbon NMR information, and mass-spectrometric confirmation when appropriate. These documents help distinguish identity verification from a simple commercial description.

Assay, Impurities, and Residuals

Assay requirements should be linked to the intended use. A discovery-stage customer may prioritize rapid availability and a practical research-grade specification, while a process-development or regulated-environment customer may require tighter control of related substances, residual solvents, water, and elemental impurities. I recommend defining acceptance criteria before ordering rather than asking for an unspecified “high-purity” grade.

Common commercial review points include assay by an agreed method, individual or total related substances, residual solvents, water content, and inorganic residues where relevant. The correct limits depend on the downstream reaction and internal quality system. Maison Chemical can discuss the required analytical package and determine which tests can be included in the lot-specific release documentation.

Applications and Application Matching

Research and Medicinal Chemistry

2-(4-Fluorophenyl)-thiophene may be considered as a building block in the preparation of substituted heteroaromatic molecules for discovery research. Its structure allows chemists to investigate how a thiophene-linked fluorophenyl fragment affects molecular size, electronic properties, and biological screening results. Any activity or suitability must be established experimentally for the final compound; the intermediate itself should not be presented as an approved active pharmaceutical ingredient.

Organic and Materials Synthesis

The compound may also be evaluated in synthetic programs involving conjugated aromatic systems and functional materials. Thiophene-containing structures are commonly explored in organic electronics, optical materials, and polymer-related research, but the value of a particular intermediate depends on the complete molecular design and subsequent functionalization. Buyers should confirm whether the supplied grade meets the requirements for their reaction sequence, purification method, and final material performance testing.

Types, Grades, and Material Options

For procurement purposes, “grade” should describe documented quality rather than a vague marketing label. A buyer may need research grade, synthesis grade, or a customized specification based on assay, impurity limits, packaging, and documentation. These categories are not automatically interchangeable, so I recommend requesting the actual specification sheet for each proposed grade.

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Material options can also differ by order size and release procedure. A small sample may be used for route screening, while a larger lot may require additional review of batch consistency, packaging configuration, and transport conditions. If the material will enter a controlled manufacturing process, the buyer should communicate change-control expectations and whether pre-shipment sample approval is required.

A Practical Selection Framework

Step 1: Define the Intended Use

First, I ask buyers whether the material is intended for route scouting, medicinal chemistry, process development, or commercial manufacturing support. This distinction affects the required assay, impurity profile, packaging, and documentation. It also helps prevent over-specifying a laboratory material or under-specifying an intermediate for a controlled process.

Step 2: Set the Quantity and Delivery Window

Provide a realistic purchasing range, such as 100 g for initial evaluation, 1 kg for process screening, or 10 kg for a larger development requirement. These quantities are examples for quotation planning, not guaranteed standard pack sizes, and availability should be confirmed for the requested lot. Buyers should also state whether they need one delivery or a scheduled supply arrangement.

Step 3: Align the Specification

Ask the supplier to confirm the available assay, analytical method, impurity controls, packaging, and release documents. If the buyer has an internal specification, sending it during the inquiry usually produces a more accurate response than requesting a generic price. Where a specification is still under development, Maison Chemical can help identify the information needed for a technically meaningful quotation.

Step 4: Evaluate the Commercial Offer

Bulk pricing should be evaluated together with minimum order quantity, sample policy, lead time, payment terms, transport route, and import documentation. A lower unit price may not represent the best total sourcing value if the supplier cannot support consistent documentation or repeat orders. I recommend comparing offers on delivered requirements and risk, not price alone.

Pricing, MOQ, and Lead-Time Considerations

The price of 2-(4-Fluorophenyl)-thiophene can vary according to order quantity, purity requirement, batch availability, packaging, testing, and destination. Because these variables change by project, I do not recommend publishing a fixed price without confirming the current commercial conditions. The most useful inquiry includes the required quantity, target specification, delivery country, preferred shipping term, and expected purchasing frequency.

Minimum order quantity should be discussed early, especially when the buyer needs a custom analytical package or a reserved production batch. Lead time may differ between available stock, scheduled production, and material requiring additional testing or documentation review. For planning purposes, buyers should request both the earliest feasible shipment date and the expected repeat-order timeline.

Supplier Evaluation Checklist

• Can the supplier confirm CAS No. 58861-48-6 and provide a lot-specific certificate of analysis?
• Is the assay method clearly identified, and can the supplier discuss related substances and residual solvents?
• Are the packaging, labeling, safety data, and transport documents suitable for the destination?
• Can the supplier support the requested quantity, including sample, 100 g, 1 kg, or larger requirements?
• Is there a clear process for repeat orders, specification changes, and pre-shipment review?
• Can the supplier communicate realistic lead times instead of making unsupported delivery guarantees?

Maison Chemical approaches this product as a B2B chemical supply project rather than a simple catalog transaction. We can review the required grade, quantity, destination, documentation, and timing before recommending a supply route. Where the customer has a defined process specification, we can use that information to clarify the quotation and identify any analytical or packaging requirements that need confirmation.

Key Takeaways

• 2-(4-Fluorophenyl)-thiophene CAS 58861-48-6 is an aromatic thiophene building block for research and chemical synthesis.
• The correct purchasing decision depends on verified identity, assay, impurity profile, documentation, packaging, and supply continuity.
• Application claims should remain project-specific; the intermediate is not automatically a pharmaceutical ingredient or validated material for every process.
• Quantity examples such as 100 g, 1 kg, and 10 kg can help structure a quotation, but actual MOQ and availability require confirmation.
• A complete inquiry should include specification, intended use, delivery destination, quantity, and documentation requirements.

Conclusion: How to Proceed with Bulk Purchasing

For buyers asking whether 2-(4-Fluorophenyl)-thiophene CAS 58861-48-6 is suitable for a project, the answer depends on the required synthesis and the quality standard applied to the intermediate. Its fluorinated aromatic thiophene structure makes it a reasonable candidate for selected research, medicinal chemistry, and advanced organic synthesis programs, but the final decision should be based on documented analytical results and application testing. The safest purchasing process begins with a clearly defined specification and a supplier capable of discussing both technical and commercial details.

To request a quotation from Maison Chemical, send the target quantity, required assay or impurity limits, intended use, destination, packaging preference, and desired delivery schedule. I can then help assess the appropriate supply option, documentation package, and next steps for sample evaluation or bulk procurement. This approach gives procurement and technical teams a clearer basis for comparing suppliers and planning a reliable supply of 2-(4-Fluorophenyl)-thiophene.

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