Phenylboronic Acid CAS 98-80-6: Uses, Properties, Handling, and Sourcing Guide

Phenylboronic acid, identified by CAS No. 98-80-6, is an important organoboron compound used mainly as a synthetic intermediate in pharmaceutical research, agrochemical development, and fine chemical manufacturing. Its most recognized role is participation in Suzuki–Miyaura coupling reactions, where it can provide a phenyl group for forming carbon–carbon bonds with suitable aryl or vinyl halides. For B2B buyers, the right purchasing decision depends on more than the chemical name: purity, analytical documentation, packaging, regulatory requirements, and supply continuity all need to match the intended process.

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Key Takeaways

• Phenylboronic acid has the molecular formula C₆H₇BO₂ and a molecular weight of approximately 121.93 g/mol.
• It is primarily selected as a phenyl-transfer reagent and building block for cross-coupling and other boronic acid transformations.
• Commercial specifications should be confirmed through the current product specification, certificate of analysis, and safety data sheet rather than assumed from the CAS number alone.
• Handling should follow the supplier’s SDS, with appropriate controls for dust, eye contact, skin contact, storage, and waste management.
• Maison Chemical can support B2B buyers with product documentation, packaging discussions, quotation evaluation, and supply planning for project-specific requirements.

Who This Guide Is For

I prepared this guide for procurement teams, process chemists, laboratory managers, pharmaceutical intermediate manufacturers, and distributors evaluating Phenylboronic Acid CAS 98-80-6. It is useful when a buyer needs to compare product grades, confirm technical suitability, or establish a reliable sourcing route for research and manufacturing activities. It is not a replacement for process validation, occupational safety review, or applicable local regulations.

Buyers may encounter different requirements depending on whether the material is intended for early-stage research, route development, pilot production, or routine commercial synthesis. A material suitable for exploratory work may not meet the documentation, impurity-control, or packaging expectations of a regulated manufacturing environment. I therefore recommend defining the application and quality requirements before requesting a final quotation.

Basic Properties and Chemical Context

Phenylboronic acid contains a phenyl group attached to a boronic acid functional group. Its molecular formula is C₆H₇BO₂, and its commonly reported molecular weight is approximately 121.93 g/mol. The material is generally supplied as a white to off-white crystalline solid, although appearance can vary with grade, storage history, and analytical inspection conditions.

Reported melting-point information is commonly in the approximate range of 216–219 °C, often with decomposition or method-dependent behavior considered during testing. This value should be treated as a reference rather than a guaranteed release specification unless it is explicitly included in the supplier’s current specification. Solubility can also depend on solvent, temperature, concentration, and water content, so process users should confirm compatibility experimentally.

Why the Boronic Acid Group Matters

The boronic acid group can participate in reversible interactions and carbon–carbon bond-forming chemistry. In Suzuki–Miyaura coupling, phenylboronic acid is commonly used with an appropriate electrophilic coupling partner, catalyst system, base, solvent, and process conditions. The actual reaction performance depends on the complete reaction design, so the raw material should not be evaluated in isolation.

Common Uses and Application Scenarios

Pharmaceutical and Medicinal Chemistry

Phenylboronic acid is widely used as a building block during the preparation of pharmaceutical intermediates and research compounds. It can introduce a phenyl substituent into a molecular framework through cross-coupling, helping chemists construct structures that may be difficult to obtain through direct substitution. Its value is especially relevant during route scouting, analog synthesis, and process development.

Agrochemical and Fine Chemical Synthesis

The same carbon–carbon bond-forming utility makes phenylboronic acid relevant to agrochemical research and specialty chemical production. It may be used in the synthesis of intermediates containing biaryl or substituted aromatic structures. The suitability of a particular grade depends on impurity limits, downstream purification capability, reaction sensitivity, and the requirements of the final product.

Research and Custom Synthesis

Academic, contract research, and custom synthesis organizations may purchase this material for small-scale screening and route development. In these settings, packaging flexibility and fast documentation access can be as important as nominal purity. For scale-up, however, the buyer should review lot consistency, analytical methods, packaging integrity, and replenishment capability before committing to a larger supply program.

Product Options and Key Specifications

Phenylboronic acid is usually evaluated by its chemical identity, assay or purity, appearance, moisture profile, residual solvents, and impurity pattern. The appropriate specification should be based on the reaction and downstream use rather than on a generic market description. If the material will enter a controlled manufacturing process, I recommend agreeing on a written specification before order placement.

Some buyers may request a higher-purity research grade, while others may prioritize a cost-effective material for a validated industrial process. These terms should not be assumed to have identical definitions across suppliers. I recommend comparing the actual test items and methods, not only the advertised purity percentage.

Handling and Storage Considerations

Phenylboronic acid should be handled according to the current safety data sheet and the risk assessment of the facility. Personnel should minimize dust generation, avoid direct contact, and use suitable eye, skin, and respiratory protection where the risk assessment indicates it is necessary. Local exhaust ventilation is a prudent control when transferring powders or performing operations that may create airborne particles.

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The material should be stored in a clean, tightly closed container under the conditions specified by the supplier. Buyers should protect the product from contamination and avoid prolonged exposure to unsuitable heat, moisture, or incompatible materials. Storage areas should also maintain clear labeling and lot traceability so that material status can be confirmed before use.

Before using a shipment, the receiving team should inspect the outer packaging, verify the product name and CAS number, and compare the lot information with the accompanying documentation. Any damaged container, unexpected appearance, or documentation discrepancy should be placed on hold for investigation. Waste handling and spill response must follow the facility’s procedures and applicable local requirements.

How to Select the Right Supplier

Step 1: Define the Technical Requirement

Start by documenting the intended reaction, target scale, required purity, packaging preference, and acceptable analytical methods. If the material will be used in a regulated or quality-controlled environment, include document expectations at the inquiry stage. This prevents avoidable delays caused by discovering requirements only after a purchase order has been issued.

Step 2: Review the Evidence

Ask for a current specification and representative certificate of analysis for review. Compare the stated test methods, impurity reporting, lot information, and product description. A supplier should be able to explain which information is standard and which items require project-specific confirmation.

Step 3: Assess Commercial Fit

Price is only one part of the sourcing decision. Evaluate quotation validity, available pack sizes, minimum order quantity, production or dispatch lead time, payment terms, export documents, and the supplier’s ability to support repeat orders. Lead time and MOQ should be confirmed for the requested quantity and destination because they can change according to inventory, packaging, and logistics conditions.

Step 4: Confirm Supply Continuity

For recurring consumption, discuss forecast visibility, batch allocation, retention samples, and change-notification expectations where relevant. It is also useful to establish how nonconformities, transport damage, and document corrections will be handled. These practical details can reduce operational risk when the material becomes part of a regular manufacturing schedule.

Common Buyer Mistakes

One common mistake is treating CAS No. 98-80-6 as a complete quality specification. The CAS number identifies the substance, but it does not define a supplier’s assay limit, impurity profile, packaging configuration, or documentation package. Another mistake is comparing prices without checking whether quotations refer to the same grade, quantity, test method, and delivery basis.

Buyers may also overlook moisture sensitivity within their specific reaction or fail to confirm whether the supplied physical form is convenient for dispensing. A laboratory-scale evaluation should not automatically be considered evidence of manufacturing suitability. I recommend a staged qualification process that moves from document review to sample evaluation and then to commercial supply approval.

Maison Chemical Supplier Support

At Maison Chemical, I approach Phenylboronic Acid CAS 98-80-6 as a technical sourcing project rather than a simple catalog transaction. We can discuss the intended application, required quantity, packaging, destination, and documentation needs before preparing a quotation. This helps us distinguish between exploratory research demand and more structured pharmaceutical intermediate or fine chemical supply requirements.

Our B2B support can include product information review, specification alignment, certificate and SDS coordination, packaging discussions, and order planning. Availability, MOQ, lead time, and commercial terms should be confirmed for each inquiry because they depend on the requested grade, quantity, and delivery requirements. We do not recommend selecting a product solely on an unverified standard claim; the final decision should be based on current documentation and technical fit.

Conclusion: A Practical Sourcing Decision

Phenylboronic acid CAS 98-80-6 is a valuable aromatic boronic acid building block, particularly for Suzuki–Miyaura coupling and related synthetic applications. The best product choice combines suitable purity and impurity control with reliable documentation, safe handling information, appropriate packaging, and realistic supply terms. Its reported molecular weight of approximately 121.93 g/mol and reference melting range of about 216–219 °C help identify the material, but they do not replace batch-specific quality review.

As the next step, define your required grade, quantity, packaging, destination, and documentation package, then request a quotation supported by the current specification and certificate of analysis. Maison Chemical can review these requirements with your procurement or technical team and help identify a suitable supply approach. Contact us with your project details so we can provide a practical B2B sourcing response for Phenylboronic Acid CAS 98-80-6.

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