What Is 2,6-Bis(benzyloxy)pyridine-3-boronic acid CAS 2096339-92-1 Used For?

2,6-Bis(benzyloxy)pyridine-3-boronic acid, identified by CAS 2096339-92-1, is primarily used as a specialized boronic acid building block in synthetic organic chemistry. Its main value comes from the boronic acid group, which can participate in palladium-catalyzed cross-coupling reactions such as Suzuki–Miyaura coupling. The protected pyridine structure also provides a functionalized heteroaromatic framework for medicinal chemistry, agrochemical research, and advanced intermediate development. I recommend treating it as a research and manufacturing intermediate rather than as a finished active ingredient.

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Direct Definition and Chemical Role

This compound contains a pyridine ring, two benzyloxy substituents at the 2- and 6-positions, and a boronic acid group at the 3-position. The benzyloxy groups can serve as protecting or functional-tuning elements during a multistep synthesis, while the boronic acid group provides a practical point for carbon–carbon bond formation. A structure-based molecular-weight estimate is approximately 335.16 g/mol, although buyers should confirm the molecular formula, salt form, hydration state, and analytical data on the supplier’s specification sheet.

The compound is generally relevant to researchers who need to introduce a substituted pyridyl fragment into a larger molecule. It is not accurate to describe the material as having one universal end use, because its final application depends on the coupling partner, reaction conditions, deprotection strategy, and target molecule. In commercial discussions, I therefore describe CAS 2096339-92-1 as a specialty intermediate for route development and custom synthesis.

Core Functions in Organic Synthesis

Suzuki–Miyaura Coupling Building Block

The most direct use of this material is as an organoboron reagent for cross-coupling with a suitable aryl or heteroaryl halide. In a successful Suzuki–Miyaura reaction, the boronic acid functionality helps connect the pyridine-containing fragment to another carbon framework. The exact catalyst, base, solvent, temperature, and reaction time must be selected experimentally, because reactivity can change with substrate electronics and steric effects.

For process development, the boronic acid group is especially useful when a project requires a substituted heteroaryl unit that would be difficult to install through direct C–H functionalization. The two benzyloxy groups may also influence solubility and steric accessibility during coupling. I recommend confirming reaction compatibility at small scale before committing to a larger quantity, particularly when the target route contains multiple sensitive functional groups.

Protected Pyridine Intermediate

The benzyloxy substituents may be used as part of a protection strategy or as deliberate substituents in the target structure. Their purpose depends on the planned downstream chemistry, including whether the synthesis requires later deprotection or transformation of the oxygen-bearing groups. Because protection and deprotection conditions can affect yield and impurity profiles, route developers should evaluate this compound within the complete synthetic sequence rather than judging it only by its name.

Potential Application Scenarios

In medicinal chemistry, this compound may be used to prepare screening compounds containing a substituted pyridine motif. Researchers can couple it with diverse aryl, heteroaryl, or selected vinyl partners to build analog libraries for structure–activity relationship studies. The material is therefore relevant to discovery laboratories that need flexible access to nitrogen-containing aromatic fragments.

In pharmaceutical intermediate research, CAS 2096339-92-1 may support the preparation of advanced intermediates rather than the final drug substance itself. Its suitability depends on the project’s impurity controls, scale requirements, reaction robustness, and downstream purification strategy. I would not assume pharmaceutical suitability from the CAS number alone; the buyer should request appropriate analytical documentation and perform its own qualification.

In agrochemical and specialty chemical research, functionalized pyridines are frequently investigated as components of more complex molecules. This compound can be considered when a project needs a protected, boronic-acid-functionalized pyridine for exploratory synthesis. However, the actual commercial relevance must be established through the buyer’s target route, regulatory review, and performance testing.

Material Options and Form Considerations

For procurement purposes, the most important distinction is usually not a different “grade” of the same product, but the quality profile required for the intended reaction. A discovery project may initially prioritize availability and sufficient purity for screening, while a process-development project may require tighter control of water, residual solvents, inorganic residues, and related substances. Packaging size, storage conditions, and documentation should be agreed before an order is placed.

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Key Specifications for B2B Evaluation

A buyer should first verify the identity and requested quantity, then review the analytical package. Useful specification fields include assay reported in %, water content reported in %, and residual solvents reported in ppm. These are evaluation categories, not claimed values for every batch, so I recommend requesting the actual batch-specific results before technical approval.

For laboratory qualification, a buyer may begin with a small sample such as 10 mg to confirm solubility, reaction behavior, and analytical response. A practical internal review can include a short screening window of 24–48 hours, depending on the test design and laboratory workload. These suggested quantities and times are project-management examples only, not guaranteed performance specifications for the product.

Analytical Information to Request

The most useful documents commonly include a certificate of analysis, chromatographic purity information, an identity spectrum, and a safety data sheet. Depending on the buyer’s quality system, additional information may include water determination, residual-solvent data, elemental analysis, or a more detailed impurity profile. If the compound is intended for a regulated development program, the documentation level should be agreed before sampling rather than after the purchase order.

Buyer Selection Factors

Price is only one part of selecting a supplier for CAS 2096339-92-1. I suggest comparing identity control, batch consistency, sample availability, packaging suitability, export documentation, communication speed, and the supplier’s ability to discuss custom requirements. A low unit price may not reduce total project cost if the material arrives with incomplete documentation or requires extensive requalification.

Lead time should also be evaluated realistically. Buyers should distinguish between material available from stock, material requiring batch preparation, and material requiring route development or custom synthesis. Before placing an order, confirm the requested quantity, delivery destination, incoterms, packaging, shelf-life information, and whether a pre-shipment document review is possible.

How Maison Chemical Can Support Procurement

At Maison Chemical, I help B2B buyers evaluate 2,6-Bis(benzyloxy)pyridine-3-boronic acid according to the actual project stage. For an early research order, the discussion may focus on sample quantity, identity confirmation, and basic analytical documentation. For a larger requirement, the review can expand to batch requirements, packaging, shipping arrangements, and any available quality specifications.

Our role is to provide a clear commercial and technical starting point without overstating what has not been verified. Buyers can share the required quantity, destination country, target specification, intended application, and desired delivery schedule so that the inquiry can be assessed accurately. Where a particular specification or document is not available, it should be identified openly before the order is finalized.

Key Takeaways

• 2,6-Bis(benzyloxy)pyridine-3-boronic acid CAS 2096339-92-1 is mainly used as a specialized heteroaryl boronic acid building block.
• Its principal synthetic function is participation in Suzuki–Miyaura and related cross-coupling chemistry.
• The substituted pyridine framework may support medicinal chemistry, agrochemical research, and advanced intermediate development.
• The two benzyloxy groups can affect protection strategy, steric environment, solubility, and downstream transformation planning.
• Buyers should confirm identity, assay, water, residual solvents, batch documentation, packaging, and delivery conditions before purchase.

Conclusion: What Is It Used For?

In direct answer, 2,6-Bis(benzyloxy)pyridine-3-boronic acid CAS 2096339-92-1 is used primarily to construct more complex pyridine-containing molecules through boronic-acid-based cross-coupling. It is especially relevant to medicinal chemistry, specialty intermediate synthesis, and research programs that need a protected and functionalized heteroaromatic fragment. Its real value depends on whether the compound fits the buyer’s reaction route, analytical requirements, and downstream processing plan.

The next practical step is to provide Maison Chemical with the required quantity, target purity, destination, intended use, and documentation expectations. We can then help clarify product availability, sample evaluation, packaging, and the information needed for a responsible B2B quotation. This approach allows the buyer to assess both chemical suitability and supply reliability before moving to a larger order.

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