What Is 2-Chlorophenylboronic Acid CAS 3900-89-8? Properties, Uses, and Supplier Specifications

2-Chlorophenylboronic acid CAS 3900-89-8 is an aryl boronic acid used primarily as a building block for organic synthesis, especially palladium-catalyzed Suzuki–Miyaura cross-coupling. It contains a benzene ring with adjacent chloro and boronic acid substituents, giving chemists two useful functional handles for designing substituted biaryl and other aromatic compounds. Its molecular formula is commonly represented as C₆H₆BClO₂, with a calculated molecular weight of approximately 156.37 g/mol. At Maison Chemical, we supply this intermediate for research, process development, and manufacturing applications, subject to agreed specifications, documentation, packaging, and logistics requirements.

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Key Takeaways

• 2-Chlorophenylboronic acid is also known as 2-chlorobenzeneboronic acid or o-chlorophenylboronic acid.
• Its principal synthetic role is as an aryl-boron coupling partner in carbon–carbon bond formation.
• The chlorine substituent can remain available for further chemical transformation, depending on the reaction system.
• Buyers should confirm identity, assay, water content, residual solvents, appearance, packaging, and batch documentation before purchase.
• Maison Chemical can discuss material grade, quantity, delivery destination, and documentation needs for a practical sourcing plan.

What Is 2-Chlorophenylboronic Acid?

2-Chlorophenylboronic acid is an aromatic organoboron compound in which a boronic acid group and a chlorine atom are attached to neighboring positions on a phenyl ring. The “2-chloro” designation indicates that the chlorine is located next to the boronic acid substituent. Its CAS Registry Number is 3900-89-8, which helps buyers distinguish it from positional isomers such as 3-chlorophenylboronic acid and 4-chlorophenylboronic acid.

The boronic acid group is the main reactive feature used in cross-coupling chemistry. Under suitable catalytic and basic conditions, it can react with an appropriate aryl or heteroaryl halide to form a carbon–carbon bond. The exact reaction outcome depends on the substrate, catalyst, base, solvent, temperature, atmosphere, and purification procedure, so the compound should be evaluated as a synthesis intermediate rather than as a universal plug-and-play reagent.

Basic Chemical Identity

Core Functions in Organic Synthesis

The most important function of 2-chlorophenylboronic acid is to provide a 2-chlorophenyl fragment during carbon–carbon bond construction. In Suzuki–Miyaura chemistry, the boronic acid group participates in transmetalation and subsequent coupling with an aryl, heteroaryl, or vinyl halide under an appropriate catalytic system. This makes the material relevant to medicinal chemistry, agrochemical research, advanced intermediates, and specialty molecule development.

The chlorine atom creates an additional design option. In some synthetic routes, it is retained in the final molecule as a substituent that influences molecular structure and properties; in other routes, it may be used in a separate transformation if the reaction conditions are selective. I recommend evaluating chemoselectivity experimentally because the reactivity of the boronic acid and aryl chloride depends strongly on the chosen catalyst and reaction partners.

Application Scenarios

Medicinal and Pharmaceutical Research

Research teams may use 2-chlorophenylboronic acid to prepare substituted biaryl compounds, heteroaryl derivatives, and focused compound libraries. Its combination of an aryl boronic acid group and an ortho chlorine substituent can support route exploration when both structural position and later-stage functionalization are important. The compound is a research or manufacturing intermediate, not an active pharmaceutical ingredient unless it has been further processed into a validated product.

Agrochemical and Specialty Chemical Development

Organoboron intermediates are used in the preparation of structurally diverse aromatic compounds. For agrochemical and specialty chemical programs, 2-chlorophenylboronic acid may be considered when a 2-chlorophenyl unit is required in a target structure. Suitability should be confirmed through route-specific experiments, impurity profiling, and process safety review.

Process Development and Scale-Up

Process chemists may evaluate this material during reaction optimization, impurity investigations, and pilot-scale preparation of downstream intermediates. At larger scale, the purchase decision should include more than assay alone. Batch consistency, analytical methods, packaging integrity, delivery reliability, and the supplier’s ability to discuss non-conforming material are also important.

Types and Material Options Buyers May Consider

Buyers generally compare 2-chlorophenylboronic acid by intended use rather than by a single universal grade label. A small research quantity may require practical packaging and a certificate of analysis, while a production program may require a tighter impurity profile, defined residual solvent limits, controlled packaging, and repeat-batch supply. The correct specification should be agreed before an order is placed.

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• Research quantity: suitable for route screening, medicinal chemistry, and analytical method development.
• Process-development quantity: appropriate when customers need repeatable material for optimization and scale-up studies.
• Manufacturing supply: evaluated through agreed assay, impurity, packaging, logistics, and change-control requirements.
• Custom specification: considered when a project requires additional testing or limits beyond a standard commercial specification.

Key Supplier Specifications to Review

Before selecting a supplier, I recommend requesting the product name, CAS number, molecular formula, molecular weight, appearance, assay method, and batch-specific test results. Identity is commonly assessed using techniques such as NMR, infrared spectroscopy, chromatography, or other methods defined by the supplier’s quality system. Buyers should verify that the analytical package clearly identifies the tested lot rather than relying only on a general product description.

Assay is important, but it should not be reviewed in isolation. Related substances, water content, residual solvents, inorganic residues, and physical appearance can affect downstream reaction performance, particularly when the material is used in a sensitive or tightly controlled process. If a specific purity target is required, I advise buyers to state the target before quotation so that Maison Chemical can assess the appropriate supply and testing route.

Storage and Handling Considerations

Handling should follow the current Safety Data Sheet and the buyer’s site procedures. As with other fine chemical intermediates, personnel should avoid generating dust, use appropriate protective equipment, and work with suitable ventilation and containment. Storage conditions should be defined from the supplier’s SDS and packaging recommendation; a controlled, dry environment is commonly considered when protecting solid intermediates from moisture and contamination, but the exact condition should be confirmed for the supplied lot.

For laboratory and process use, buyers should also confirm whether the material is supplied as a solid, the recommended container type, net weight tolerance, and any special transport requirements. I do not recommend assuming that a material is suitable for a particular reaction solely because its name and CAS number match. A small compatibility or performance check can reduce the risk of discovering specification issues after scale-up.

Buyer Selection Factors

1. Confirm identity: Match the product name, CAS 3900-89-8, structure, formula, and molecular weight with the project requirement.
2. Define quality: Specify assay, impurity limits, water content, residual solvents, and required analytical methods.
3. Check batch documentation: Request a batch-specific certificate of analysis and the current Safety Data Sheet.
4. Evaluate quantity: Align the requested pack size or batch size with laboratory, development, or manufacturing needs.
5. Review logistics: Confirm lead time, destination, export documents, packaging, and shipment conditions before issuing a purchase order.
6. Assess continuity: Discuss repeat supply, forecast visibility, change notification, and handling of quality deviations.

How Maison Chemical Supports B2B Buyers

At Maison Chemical, we focus on making the sourcing process clear from the first technical inquiry. We can discuss the required quantity, intended application, target specification, packaging format, destination, and documentation package before preparing a commercial proposal. This approach helps separate a simple laboratory purchase from a project that requires development or manufacturing support.

Our support can include product identification review, specification alignment, batch documentation discussion, packaging coordination, and shipment planning. We do not treat a generic purity statement as a substitute for project requirements. If your team needs a specific assay level, impurity control, analytical method, or delivery schedule, please provide those details so we can respond conservatively and accurately.

Conclusion: Is 2-Chlorophenylboronic Acid CAS 3900-89-8 Suitable for Your Project?

2-Chlorophenylboronic acid CAS 3900-89-8 is a useful aryl boronic acid intermediate for constructing substituted aromatic molecules, especially through Suzuki–Miyaura coupling. Its approximate molecular weight is 156.37 g/mol, and its adjacent boronic acid and chlorine substituents provide meaningful flexibility for route design. However, reaction suitability, storage, and final product quality must be confirmed against the specific process and current supplier documentation.

The next practical step is to define your required quantity, target assay, impurity expectations, packaging, destination, and delivery window. Send these details to Maison Chemical for a focused quotation and specification review for 2-Chlorophenylboronic acid CAS 3900-89-8. We can then help you determine whether a standard research supply or a more controlled B2B specification is the better fit.