What Is 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3? Properties, Uses, and Supplier Information

2-Fluoro-4-(trifluoromethyl)phenylboronic acid, identified by CAS No. 503309-11-3, is a fluorinated aryl boronic acid used primarily as a synthetic building block. I supply and support this type of pharmaceutical and specialty chemical intermediate for research, process development, and manufacturing programs that require a defined boronic acid functionality. Its principal value comes from the combination of an aryl boronic acid group, one fluoro substituent, and one trifluoromethyl substituent in the same molecule. These features make it a useful partner for carbon–carbon bond-forming reactions, especially Suzuki–Miyaura coupling, subject to project-specific reaction validation.

Please visit our website for more information on this topic.

Key Takeaways

• 2-Fluoro-4-(trifluoromethyl)phenylboronic acid is an aromatic boronic acid intermediate with CAS No. 503309-11-3.
• Its commonly assigned molecular formula is C₇H₅BF₄O₂, with a calculated molecular weight of approximately 207.92 g/mol.
• The molecule contains four fluorine atoms in total: one ring-bound fluorine and three fluorines in the trifluoromethyl group.
• Its main synthetic use is as a coupling component for preparing substituted biaryl or related aromatic structures.
• Buyers should confirm identity, assay, water content, residual solvents, packaging, storage conditions, and batch documentation before placing a commercial order.

Identity and Chemical Definition

What the name means

The name describes the structure of the compound. “Phenylboronic acid” indicates an aromatic ring connected to a boronic acid group, generally represented as Ar–B(OH)₂. The “2-fluoro” designation identifies a fluorine substituent at the second position relative to the boronic acid group, while “4-(trifluoromethyl)” identifies a –CF₃ group at the fourth position. This positional arrangement is important because substituent location can influence reaction behavior, downstream molecular properties, and analytical identification.

For purchasing and documentation, the CAS number is the primary reference used to distinguish this material from other fluorinated phenylboronic acids. I recommend using the CAS number together with the complete chemical name, molecular formula, and a supplier specification because similar compounds may differ only in the position of fluorine or trifluoromethyl substitution. A structure file or internal material code can further reduce the risk of selecting an isomer.

Basic calculated properties

The formula and molecular weight above are calculated from the stated structure and should be checked against the supplier’s current certificate of analysis and product specification. Physical appearance, melting behavior, solubility, and stability can vary with purity, hydration state, residual solvent, particle form, and storage history. For that reason, I avoid treating a general database value as a substitute for lot-specific documentation.

Core Functions in Organic Synthesis

Partner for cross-coupling reactions

The most important function of this compound is to provide a fluorinated aryl fragment in a coupling reaction. In a Suzuki–Miyaura reaction, the boronic acid group can react with a suitable aryl or heteroaryl halide under an appropriate catalyst, base, solvent, and temperature system. The boronic acid portion is used to form a new carbon–carbon bond, while the boron-containing group is removed during the reaction sequence. Actual conversion and selectivity depend on the reaction substrate and process conditions.

This makes CAS 503309-11-3 relevant to medicinal chemistry libraries, lead optimization, process research, and the preparation of advanced intermediates. The fluorine and trifluoromethyl substituents remain part of the coupled aromatic fragment unless a later transformation is intentionally designed to modify them. Their electronic and lipophilic effects may be useful when researchers are adjusting the properties of a candidate molecule, although the final effect must be evaluated in the specific molecular context.

Building block for fluorinated molecules

Fluorinated aromatic fragments are frequently considered during pharmaceutical and agrochemical research because fluorine substitution can change molecular electronics, metabolic behavior, polarity, and lipophilicity. However, the presence of fluorine does not by itself establish a biological or commercial performance advantage. I position this material as a reaction-ready building block rather than as a finished active ingredient or a guaranteed solution for any particular discovery program.

Potential Application Scenarios

One application scenario is the synthesis of substituted biaryl compounds. A buyer may pair this boronic acid with an aryl, heteroaryl, or vinyl electrophile during route scouting, provided the selected reaction system is compatible with the substrate. Another scenario is the preparation of fluorinated fragments for medicinal chemistry screening, where small quantities are used to create analogues around a common scaffold. The compound may also be evaluated in process development when a selected route requires this specific substitution pattern.

In scale-up work, the material must be assessed beyond its reaction yield. Process teams commonly examine charging behavior, impurity clearance, isolation, drying, solid handling, and reproducibility between lots. A supplier’s consistent identity testing and controlled packaging can therefore be as important as the nominal assay value. I recommend testing the actual purchased batch in the intended reaction before making a larger commitment.

Handling, Storage, and Quality Considerations

Handling expectations

As with other boronic acids and fluorinated organic intermediates, this compound should be handled according to its current safety data sheet and site chemical-hygiene procedures. Users should avoid creating dust, use suitable personal protective equipment, and work with appropriate ventilation. The correct hazard classification, transport status, and emergency measures must be taken from the product-specific SDS rather than inferred only from the chemical name.

For more information, please visit Maison Chemical.

Boronic acids can be sensitive to moisture, prolonged heat, and unsuitable storage environments, but the actual stability profile should be confirmed through supplier data or an internal stability study. Buyers should keep the original container properly closed and use the storage temperature stated on the applicable product documentation. If a project has a defined retest period, I recommend requesting supporting stability information before purchasing a large quantity.

Specifications buyers should request

A practical B2B specification should include identity, assay or purity method, appearance, water content where relevant, residual solvents, and selected elemental or inorganic impurities. Depending on the application, buyers may also request HPLC, NMR, LC–MS, or other analytical data that confirms the expected structure. The acceptable limits should be agreed before production rather than changed after delivery.

For regulated or highly controlled development programs, documentation may include a certificate of analysis, safety data sheet, batch number, manufacturing date, retest or review date, packaging description, and country-of-origin information. These documents do not replace a customer’s own qualification process, but they help the buyer evaluate whether the material is suitable for the intended stage of work.

How to Select a Supplier

Confirm material identity and batch consistency

I recommend starting with a direct identity check against CAS No. 503309-11-3 and the intended structure. The supplier should be able to state whether the offered grade is research grade, synthetic grade, or manufactured to a customer-specific specification. If the compound is being used in a multi-step route, ask whether the supplier can maintain consistent impurity controls across repeat batches.

Match quantity, packaging, and delivery requirements

Small development projects may require only gram-scale quantities, while process studies can require larger packages and repeat supply. A supplier should clarify available pack sizes, minimum order quantity, production lead time, sample availability, and whether a larger quantity is produced from the same or a comparable process. Packaging should protect the material from contamination and environmental exposure while remaining practical for laboratory or manufacturing handling.

Price should be evaluated together with assay, documentation, packaging, lead time, and supply continuity. A lower unit price may not represent lower total cost if the material requires additional testing, arrives in an unsuitable package, or cannot be replenished on schedule. I help buyers compare these factors before quotation so that the selected option fits both technical and procurement requirements.

Maison Chemical Supplier Support

At Maison Chemical, I support B2B buyers sourcing pharmaceutical intermediates and specialty chemicals by focusing on clear specifications and practical communication. For 2-Fluoro-4-(trifluoromethyl)phenylboronic acid, I can help review the required quantity, target purity, packaging preference, documentation package, and intended application stage. Where a standard specification does not match a project, the requirements should be discussed before order confirmation.

Our support approach is based on confirming what can be documented rather than making unsupported claims about performance or regulatory status. We can discuss sample evaluation, batch documentation, shipping preparation, and repeat-order planning according to the inquiry. Buyers should provide their required specification, destination, target quantity, and delivery schedule so the quotation can be prepared against the actual project need.

Conclusion: Is This the Right Intermediate for Your Project?

2-Fluoro-4-(trifluoromethyl)phenylboronic acid CAS 503309-11-3 is a defined fluorinated aryl boronic acid and a useful synthetic intermediate for coupling-based preparation of substituted aromatic compounds. Its key structural data include the approximate formula C₇H₅BF₄O₂, a calculated molecular weight of approximately 207.92 g/mol, and four fluorine atoms. Its suitability depends on reaction compatibility, required purity, handling conditions, and the documentation needed for your project.

The next step is to compare the exact structure, specification, quantity, packaging, and delivery requirements with a qualified supplier. Contact Maison Chemical with your target quantity, purity requirement, destination, and documentation needs, and I can help prepare a practical B2B supply assessment for this intermediate.

For more 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3information, please contact us. We will provide professional answers.