What Is 4-Trifluoromethylphenylboronic Acid CAS 128796-39-4? Uses, Specifications, and Buying Guide

4-Trifluoromethylphenylboronic acid, identified by CAS 128796-39-4, is an aryl boronic acid used mainly as a building block in cross-coupling chemistry. I describe it as a para-substituted phenylboronic acid containing both a boronic acid group and a trifluoromethyl group. Its molecular formula is C₇H₆BF₃O₂, and its molecular weight is approximately 189.93 g/mol. In practical B2B sourcing, buyers should evaluate identity, assay, impurity profile, packaging, documentation, and supply consistency rather than relying on the chemical name alone.

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What Is 4-Trifluoromethylphenylboronic Acid?

4-Trifluoromethylphenylboronic acid is an organoboron compound in the aromatic boronic acid family. The boronic acid group is attached to a phenyl ring, while the trifluoromethyl group is positioned at the para, or 4-position, relative to the boronic acid functionality. This substitution pattern gives the molecule a defined structure that is relevant when chemists are planning regioselective synthesis routes.

The boronic acid group is the principal reactive handle in many palladium-catalyzed Suzuki–Miyaura coupling reactions. During a typical coupling, the arylboronic acid reacts with an aryl or vinyl halide, pseudohalide, or related electrophilic partner to form a new carbon–carbon bond. The trifluoromethyl group generally remains incorporated in the product and can influence the electronic and physicochemical profile of the resulting molecule.

Key identity information

Core Functions and Chemical Uses

I commonly position this material as a synthetic intermediate rather than as a final-use ingredient. Its primary function is to transfer a 4-trifluoromethylphenyl group into a target molecule through carbon–carbon bond-forming chemistry. This makes it useful for medicinal chemistry libraries, process development, agrochemical research, and the preparation of advanced aromatic intermediates.

The trifluoromethyl substituent is often selected by synthetic chemists when they want to modify the electronic character, lipophilicity, metabolic behavior, or overall molecular design of a candidate compound. However, the final effect depends on the complete molecular structure and reaction sequence. I therefore recommend treating this compound as a versatile building block, not as a guarantee of a particular performance outcome in a finished product.

Typical reaction role

• Reactant for Suzuki–Miyaura aryl coupling.
• Source of a para-trifluoromethyl-substituted aryl fragment.
• Intermediate for pharmaceutical and discovery chemistry synthesis.
• Building block for advanced aromatic and heteroaromatic compounds.
• Material for route scouting, scale-up studies, and process optimization.

Application Scenarios

In pharmaceutical research, this boronic acid can support the preparation of analogues containing a trifluoromethylphenyl motif. Research teams may use it when screening structural variations or developing a practical synthetic route to a new compound. The most suitable reaction conditions depend on the coupling partner, catalyst system, base, solvent, temperature, and desired scale.

In agrochemical and specialty chemical development, the same building block can be used to introduce a fluorinated aromatic segment into a more complex structure. It may also be relevant to contract research organizations and custom synthesis laboratories that need a defined arylboron reagent for small-scale or multi-step programs. Because performance is route-dependent, laboratory validation remains necessary before commercial process adoption.

Types, Grades, and Material Options

Commercially, buyers may encounter this product in different package sizes and quality grades rather than fundamentally different chemical forms. A research-grade material may be appropriate for route discovery, while a higher-control grade may be more suitable for process development or regulated project support. The correct choice depends on the intended use, impurity sensitivity, batch size, and documentation requirements.

Some suppliers may offer standard stock, while others provide made-to-order production or project-based supply. I advise buyers to confirm whether the quoted material is available from existing inventory or requires a new production campaign. This distinction can affect lead time, minimum order quantity, batch documentation, and the feasibility of repeat purchasing.

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What buyers should confirm

• Correct CAS number and chemical structure.
• Assay method and reported purity specification.
• Water content, residual solvents, and relevant inorganic impurities.
• Appearance and physical form as stated on the product specification.
• Batch number, manufacturing date, retest or review date, and certificate of analysis.
• Safety data sheet, packaging details, and transport classification where applicable.

Key Specifications and Handling Considerations

The molecular weight of approximately 189.93 g/mol is useful for reaction calculations, inventory planning, and scale conversion. For example, a theoretical charge of 18.993 g corresponds to approximately 0.100 mol before correcting for assay and actual material composition. In production work, I recommend calculating the required mass from the supplier’s batch-specific assay rather than assuming a nominal value.

Appearance, solubility, stability, and moisture behavior should be verified from the current technical data sheet and certificate of analysis. Boronic acids can be sensitive to storage conditions, moisture exposure, prolonged heat, or repeated opening, depending on the specific compound and packaging system. Buyers should follow the supplier’s SDS and label instructions, keep the container tightly closed, and request handling guidance before committing to a large quantity.

How to Select a Reliable Supplier

When I evaluate a supplier for 4-Trifluoromethylphenylboronic acid, I begin with technical transparency. A credible supplier should be able to provide a clear product specification, current SDS, batch documentation, and realistic information about stock or production timing. I also look for a defined communication process for questions about assay, packaging, custom requirements, and repeat orders.

Price should be considered together with usable quality, delivery reliability, documentation, and the cost of failed or delayed experiments. A lower quoted price may not be beneficial if the package size is unsuitable, the batch data are incomplete, or the supplier cannot support repeat supply. For international purchasing, buyers should additionally confirm export paperwork, labeling, customs information, and the responsibilities of each party under the agreed shipping terms.

Practical B2B selection checklist

1. Confirm that the quotation refers specifically to CAS 128796-39-4.
2. Define the required grade, assay target, quantity, and packaging.
3. Request a representative or batch-specific certificate of analysis.
4. Review SDS, storage instructions, and transport documentation.
5. Ask whether the quoted quantity is in stock or made to order.
6. Discuss sample availability, MOQ, lead time, and repeat-order planning.
7. Clarify technical support for scale-up or impurity investigations.

How Maison Chemical Supports Buyers

At Maison Chemical, I support B2B customers seeking 4-Trifluoromethylphenylboronic acid CAS 128796-39-4 for research, development, and commercial sourcing evaluation. My role is to help buyers align the requested grade and quantity with the application, while keeping product identity and documentation requirements clear from the beginning. Availability, packaging, lead time, and commercial terms should be confirmed for each inquiry because they can vary by order scale and production schedule.

I can help organize the information needed for an efficient purchasing decision, including product specifications, COA requirements, SDS documentation, packaging options, and shipping considerations. For customers developing a repeat-use program, I also recommend discussing forecast quantities and acceptable quality parameters before the first larger order. This approach can reduce avoidable differences between laboratory purchasing and later process requirements.

Summary Insight

4-Trifluoromethylphenylboronic acid CAS 128796-39-4 is a defined arylboronic acid building block with a molecular weight of approximately 189.93 g/mol. Its main value is the ability to introduce a para-trifluoromethylphenyl group into more complex molecules, particularly through Suzuki–Miyaura coupling. The best purchasing decision depends on verified identity, batch-specific quality data, suitable packaging, handling information, and dependable supply support.

My recommended next step is to prepare your required quantity, target assay, application, packaging preference, and delivery destination before requesting a quotation. Contact Maison Chemical with these details so we can review the appropriate product documentation, availability, MOQ, lead time, and export requirements for your project.

Contact us to discuss your requirements of 4-Trifluoromethylphenylboronic acid CAS 128796-39-4. Our experienced sales team can help you identify the options that best suit your needs.