What Is Pyridine-4-boronic acid CAS 1692-15-5? Properties, Uses, and Supplier Specifications
What Is Pyridine-4-boronic Acid CAS 1692-15-5? Properties, Uses, and Supplier Specifications
Pyridine-4-boronic acid CAS 1692-15-5 is a heteroaryl boronic acid used mainly as a building block in palladium-catalyzed Suzuki–Miyaura cross-coupling and related organic synthesis. Its molecule combines a pyridine nitrogen with a boronic acid group, allowing chemists to introduce a pyridin-4-yl fragment into more complex compounds. I supply this material through Maison Chemical for research, process development, and manufacturing programs that require documented identity, suitable packaging, and commercially practical sourcing.
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The commonly reported molecular formula is C5H6BNO2, with a molecular weight of approximately 122.92 g/mol. It is generally handled as a solid organic intermediate, but its exact appearance, assay, water content, and storage behavior should be confirmed against the supplier’s current specification and certificate of analysis. This article explains the material’s function, applications, specification points, and the purchasing questions I recommend asking before placing an order.
What Is Pyridine-4-boronic Acid?
Pyridine-4-boronic acid is a boronic acid derivative in which the boronic acid group is attached at the 4-position of a pyridine ring. The pyridine nitrogen contributes heteroaromatic character and can influence the polarity, coordination behavior, and reactivity of the molecule. The boronic acid group is the principal coupling handle used to connect the pyridyl fragment with suitable aryl or vinyl partners.
CAS Registry Number 1692-15-5 is the key identifier buyers use to distinguish this compound from related pyridyl boronic acids and protected boronate esters. Related materials may include pyridine-3-boronic acid, pyridine-2-boronic acid, or pyridine-4-boronic acid pinacol ester; these are not automatically interchangeable because their reactivity, handling, molecular weight, and process performance can differ. I therefore recommend verifying the CAS number, chemical name, molecular formula, and structural representation together.
Core Functions and Chemical Value
Suzuki–Miyaura Coupling Building Block
The most established synthetic role of Pyridine-4-boronic acid is as a coupling partner in carbon–carbon bond formation. Under an appropriate catalytic system, the boronic acid group can react with an aryl or vinyl halide to form a new C–C bond while incorporating a pyridin-4-yl unit into the target molecule. The exact yield and selectivity depend on the substrate, catalyst, base, solvent, temperature, and reaction work-up, so I do not treat a generic product specification as a guarantee of performance in every reaction.
Heteroaromatic Intermediate
The pyridine ring is valuable in medicinal chemistry, agrochemical research, ligand design, and advanced materials development because it provides a nitrogen-containing aromatic motif. After coupling, the resulting product may undergo further functionalization at other positions or through the pyridine nitrogen. This makes CAS 1692-15-5 useful for building small libraries of structurally related compounds during discovery and process research.
Key Properties and Identification Data
For routine purchasing, I recommend using a concise identity package rather than relying only on a product name. The table below summarizes commonly used identification information, while lot-specific values should be confirmed in the current technical data sheet or certificate of analysis.
| Property | Typical identification information | Buyer verification point |
|---|---|---|
| Chemical name | Pyridine-4-boronic acid; 4-pyridylboronic acid | Confirm the 4-position and CAS 1692-15-5 |
| CAS number | 1692-15-5 | Check against the purchase order and label |
| Molecular formula | C5H6BNO2 | Confirm whether the specification refers to the anhydrous material |
| Molecular weight | Approximately 122.92 g/mol | Use the supplier’s stated value for calculations |
| Physical form | Solid intermediate | Confirm color, particle form, and packaging description |
| Purity target | Often specified as a percentage by HPLC or another validated method | Request the exact acceptance limit and test method |
Boronic acids can be sensitive to moisture, prolonged heat, and storage conditions, and some may show variable behavior during analysis or isolation. For that reason, I advise buyers to review water content, assay basis, residual solvents, and storage instructions rather than judging quality from appearance alone. If the compound is intended for a sensitive coupling sequence, a small-scale compatibility trial remains appropriate.
Applications of Pyridine-4-boronic Acid CAS 1692-15-5
Pharmaceutical and Medicinal Chemistry
Researchers use this intermediate to prepare pyridyl-containing compounds for screening, lead optimization, and route development. The material can help introduce a 4-pyridyl group into molecules designed to explore hydrogen-bonding, polarity, or coordination effects. Its use in a specific active pharmaceutical ingredient route must be assessed against the full synthetic pathway, impurity profile, and applicable regulatory requirements.
Agrochemical and Fine Chemical Research
Pyridine-containing structures also appear in research programs for crop protection and other specialty chemicals. CAS 1692-15-5 can serve as one fragment in a multi-step synthesis where controlled aromatic substitution is required. In these applications, consistent identity and lot-to-lot analytical documentation are often more important than selecting the lowest nominal price.
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Ligands, Materials, and Academic Synthesis
The pyridine nitrogen may participate in coordination chemistry, while the boronic acid group provides a practical route for connecting the ring to other aromatic systems. This combination can support exploratory work on ligands, fluorescent molecules, functional materials, and chemical probes. Actual suitability depends on the target structure and reaction conditions, so buyers should define the intended transformation before choosing between the free boronic acid and a protected ester.
Free Boronic Acid or Protected Boronate Ester?
The free acid is often selected when the synthetic procedure is designed around direct Suzuki coupling or when the user wants to avoid a separate deprotection step. A pinacol ester or another protected boronate may offer different storage, weighing, or process characteristics, but it has a different molecular formula and molecular weight and should be treated as a separate commercial product. I recommend comparing both options using reaction compatibility, stability requirements, analytical method, and total process cost.
Buyers should not assume that a higher assay value alone makes one form better. A protected ester can be convenient in one route, while the free acid may be preferable in another route involving hydrolysis, telescoping, or a specific catalyst system. The correct choice is the one supported by the intended chemistry and documented handling requirements.
Supplier Specifications Buyers Should Verify
Identity and Quality Documentation
Before purchasing, I recommend requesting the product specification, current certificate of analysis, analytical method, and safety data sheet. Useful quality fields may include appearance, identification by suitable spectroscopy or chromatography, assay, related substances, water content, residual solvents, and inorganic residues. The acceptance limits should be clear, and the test results should be traceable to the relevant batch.
Packaging, Storage, and Shipment
Packaging should protect the material from contamination and excessive moisture during storage and transport. The buyer should verify the container type, net quantity, lot number, manufacturing or retest information where applicable, and recommended storage conditions. For international orders, I also review the shipping documentation, labeling requirements, export paperwork, and whether the requested packaging is suitable for the destination market.
Commercial Details
Price depends on quantity, purity target, packaging, analytical requirements, production status, and shipping destination. Minimum order quantity and lead time should be quoted for the specific grade rather than assumed from a catalog listing. As a practical benchmark, buyers may compare samples at the gram scale with development quantities from 100 g or more, but the available pack sizes and production schedule must be confirmed with the supplier.
How I Help Buyers Source CAS 1692-15-5
At Maison Chemical, I help customers evaluate Pyridine-4-boronic acid according to the intended application instead of treating every inquiry as a standard catalog transaction. I can discuss the required quantity, target purity, documentation package, packaging format, destination, and whether the free acid or a related boronate option is more appropriate for the project. Any specification, lead time, or customization commitment is confirmed on an order-specific basis.
For a technically useful quotation, I recommend sending the CAS number, estimated annual or project quantity, desired purity, required documents, delivery country, and target delivery date. If the material will enter a regulated or quality-controlled process, it is also helpful to identify whether additional testing, retained samples, or a customer-specific specification is required. This information allows Maison Chemical to provide a more relevant commercial response.
Key Takeaways
- Pyridine-4-boronic acid CAS 1692-15-5 is a heteroaryl boronic acid used mainly to introduce a pyridin-4-yl group through cross-coupling chemistry.
- Its commonly reported formula is C5H6BNO2, and its molecular weight is approximately 122.92 g/mol.
- Applications include pharmaceutical research, agrochemical synthesis, fine chemicals, ligands, and functional materials.
- Buyers should verify identity, assay, water content, impurities, packaging, storage, documentation, MOQ, and lead time for the specific lot.
- The free acid and protected boronate esters are related but distinct products and should not be substituted without checking the process chemistry.
Conclusion: Is Pyridine-4-boronic Acid CAS 1692-15-5 Right for Your Project?
Pyridine-4-boronic acid CAS 1692-15-5 is a practical pyridyl building block when a synthesis requires a boronic acid coupling handle and a pyridine nitrogen in the final structure. Its value is strongest in routes where the 4-pyridyl fragment supports the target molecule’s design and where the supplier can provide suitable identity and quality documentation. It is not a universal replacement for other pyridyl boronic acids or boronate esters.
As the next step, define the target reaction, required quantity, purity, documentation, packaging, and delivery location. Then ask Maison Chemical for a product specification, batch-specific analytical information, quotation, MOQ, and estimated lead time. I can support a structured evaluation so your purchasing decision reflects both chemical suitability and practical supply requirements.
Contact us to discuss your requirements of Pyridine-4-boronic acid CAS 1692-15-5. Our experienced sales team can help you identify the options that best suit your needs.