1,4-Cyclohexanedione Monoethylene Acetal CAS 4746-97-8: Specification, Uses, SDS, and Bulk Buying Guide

If you are sourcing 1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8, I recommend evaluating four items first: chemical identity, batch specification, SDS documentation, and supplier reliability. This compound is a protected cyclohexanedione intermediate with one ketone group available for further reaction and one carbonyl protected as a cyclic ethylene acetal. Its commonly stated molecular formula is C₈H₁₂O₃, and its molecular weight is approximately 156.18 g/mol.

For more information, please visit our website.

At Maison Chemical, I treat this product as a project-specific pharmaceutical and fine-chemical intermediate rather than a generic commodity. The correct purchase decision depends on the intended synthesis, required assay, impurity profile, packaging, documentation, and delivery schedule. Because commercial specifications can vary by manufacturing route and quality agreement, buyers should confirm the current product specification and SDS before placing a bulk order.

Who This Guide Is For

This guide is intended for pharmaceutical intermediate manufacturers, medicinal chemistry teams, process development groups, custom synthesis companies, and purchasing departments evaluating CAS 4746-97-8. It is also useful for distributors that need a consistent technical file before adding the material to their portfolio. I focus here on practical B2B qualification rather than presenting unverified performance claims.

The compound may be considered when a synthesis requires a cyclohexanone functionality together with a protected second carbonyl. It should not be selected solely by CAS number or lowest quoted price. A buyer should match the material to the reaction route, scale, analytical method, and regulatory requirements of the final project.

Basic Chemical Concept and Identification

1,4-Cyclohexanedione monoethylene acetal contains a cyclohexanone ring in which one carbonyl has been converted into an ethylene ketal. This protection strategy can help differentiate the reactivity of the two original carbonyl groups during multistep synthesis. The remaining ketone may then participate in transformations such as condensation, reduction, oxidation, or other route-specific reactions, subject to process validation.

Specification Review for CAS 4746-97-8

A useful specification should identify the product, define the quality attributes, and state the analytical methods or acceptance criteria used by the supplier. Typical review items may include appearance, assay, water content, residual solvents, related substances, and residue on ignition or other route-relevant parameters. I do not recommend assuming a numerical limit unless it appears in the current batch specification or quality agreement.

Identity and Assay

Identity testing may use techniques such as nuclear magnetic resonance, infrared spectroscopy, mass spectrometry, or chromatography, depending on the supplier’s validated or controlled procedure. Assay is normally reported as a percentage, but the basis and method should be confirmed because different laboratories may calculate results differently. For development work, I advise buyers to request a representative certificate of analysis and compare the reported method with their internal testing plan.

Impurities, Water, and Residual Solvents

Impurity control is particularly important when the material enters a multistep pharmaceutical route. Water and residual solvent levels can influence reaction reproducibility, crystallization, storage behavior, and downstream purification. If the process is moisture-sensitive or solvent-sensitive, the purchase specification should include those parameters with agreed limits rather than relying only on an assay value.

Appearance and Packaging Condition

The product’s appearance should be documented in the specification and checked at receipt. Buyers should also inspect the container seal, label, lot number, net weight, and any visible evidence of damage or moisture exposure. Packaging selection should reflect the order size, transport conditions, and the customer’s internal handling procedures; I confirm these details during quotation rather than applying one package format to every project.

Common Uses and Application Matching

CAS 4746-97-8 is generally considered a building block for organic synthesis and pharmaceutical intermediate development. Its value comes from the combination of a reactive ketone and a protected carbonyl equivalent in one molecule. This arrangement can support route design where selective functionalization is needed before the acetal is removed under suitable conditions.

If you want to learn more, please visit our website Maison Chemical.

Potential use areas include medicinal chemistry, process research, custom synthesis, and the preparation of more advanced intermediates. The actual reaction suitability depends on catalysts, solvents, temperature, water content, work-up conditions, and the required impurity profile. I recommend running a small-scale compatibility assessment before committing to a large commercial quantity.

How to Select the Right Material

1. Define the synthetic role. Confirm whether the material is being used as a protected diketone intermediate, a route-development reagent, or a starting point for a specific downstream transformation.
2. Set the quality requirements. Identify the minimum assay, impurity limits, water requirement, residual solvent limits, and analytical documentation needed for your process.
3. Request a sample or technical package. Review the certificate of analysis, SDS, product specification, packaging information, and available lot data before approving the supplier.
4. Check scale-up conditions. Confirm available quantities, batch size, manufacturing capacity, lead time, and whether the same quality standard can be maintained for repeat orders.
5. Approve the commercial terms. Align on Incoterms, packaging, labeling, transport classification, payment terms, and the process for handling deviations or complaints.

For early development, I usually recommend comparing a laboratory sample with a larger pilot quantity before production procurement. This staged approach can reveal differences in solubility, impurity behavior, filtration, or reaction performance that are not obvious from the name alone. It also helps the buyer establish an internal reference method before approving routine deliveries.

SDS and Documentation Requirements

An SDS should be available for the specific product and supplier, not copied from an unrelated chemical with a similar name. The document should be reviewed for product identification, hazard classification, first-aid measures, handling and storage, exposure controls, transport information, stability, and disposal guidance. Local regulatory requirements may differ by destination, so the importer or downstream user should confirm whether additional regional documentation is needed.

I recommend requesting the latest SDS revision together with the certificate of analysis and specification. The documents should use consistent product identification, including CAS 4746-97-8 where applicable, and should correspond to the material being quoted. If your organization requires additional declarations, such as residual solvent statements, origin information, or restricted-substance questionnaires, those requirements should be communicated before order confirmation.

Bulk Buying: MOQ, Lead Time, and Cost Factors

Pricing for this type of intermediate depends on purity target, production scale, packaging, testing, transport route, and whether the material is available from existing inventory. A lower unit price may not represent the lowest total cost if it requires extended lead time, additional testing, or larger-than-needed minimum order quantities. I therefore quote bulk projects after confirming the required quantity, specification, destination, and documentation package.

Buyers should ask for separate options for sample, development, pilot, and routine production quantities. A practical purchasing plan may compare 100 g laboratory evaluation, 1 kg process assessment, and larger production quantities, but these are planning examples rather than fixed Maison Chemical package sizes. Lead time must also be confirmed for each quantity because stocked material and made-to-order material follow different supply schedules.

Supplier Evaluation Checklist

• Can the supplier confirm the chemical identity, CAS number, formula, and approximate molecular weight?
• Is a current specification and lot-specific certificate of analysis available?
• Can the supplier provide an SDS suitable for the intended shipping destination?
• Are assay, impurities, water, and residual solvent requirements clearly defined?
• Can the supplier support sample evaluation and repeat commercial supply?
• Are packaging, labeling, transport, and storage conditions documented?
• Is there a clear process for technical questions, deviations, and quality complaints?

At Maison Chemical, I support buyers by organizing the product specification, SDS, quotation details, packaging discussion, and application information around the actual project. Our role is to help customers assess whether the offered grade fits their process, not to replace their internal quality or regulatory approval. Final acceptance should remain with the customer’s qualified technical and procurement teams.

Key Takeaways

• CAS 4746-97-8 is 1,4-Cyclohexanedione monoethylene acetal, a protected cyclohexanedione intermediate.
• The commonly stated formula is C₈H₁₂O₃, with an approximate molecular weight of 156.18 g/mol.
• Selection should cover identity, assay, impurities, water, residual solvents, packaging, SDS, and repeat-supply capability.
• Bulk purchasing should be based on the complete cost and risk profile, not unit price alone.
• A sample, technical review, and agreed specification can reduce avoidable scale-up and sourcing problems.

Conclusion: A Practical Next Step for Buyers

1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 can be a useful synthetic intermediate when its protected-carbonyl structure matches the reaction route. The most reliable buying decision comes from confirming the exact specification, reviewing the SDS, testing a representative sample, and aligning quantity and delivery requirements with the supplier. A CAS number establishes identity, but it does not by itself define purity, impurity limits, packaging, or commercial consistency.

If you are evaluating this material for pharmaceutical intermediate development or bulk production, prepare your target quantity, required assay, destination, documentation requirements, and intended application before requesting a quotation. Maison Chemical can then review the project and provide current product information, supply options, and a B2B quotation for 1,4-Cyclohexanedione monoethylene acetal.

If you are looking for more details, kindly visit 1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8.