4-Pyrazoleboronic Acid Pinacol Ester CAS 269410-08-4: Product, Uses, Specifications, and Buying Guide

If you are sourcing 4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4, you are typically looking for a boron-containing heterocyclic building block for synthetic chemistry, medicinal chemistry, or pharmaceutical intermediate development. I identify this product as a protected pyrazole boronic ester, commonly used in palladium-catalyzed cross-coupling reactions such as Suzuki–Miyaura coupling. Its commonly associated molecular formula is C₉H₁₅BN₂O₂, with a calculated molecular weight of approximately 194.04 g/mol. At Maison Chemical, I help buyers evaluate identity, purity, documentation, packaging, and supply suitability before placing a commercial order.

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Who This Buying Guide Is For

This guide is intended for procurement teams, process chemists, medicinal chemistry researchers, pharmaceutical intermediate manufacturers, and distributors evaluating CAS 269410-08-4. It is also useful for buyers comparing small laboratory quantities with larger development or production requirements. Because commercial specifications can differ by supplier and application, I recommend treating the information below as a sourcing framework rather than a replacement for a current certificate of analysis.

The main purchasing question is not simply whether a supplier lists the correct CAS number. A reliable decision should also consider chemical identity, assay method, impurity profile, batch consistency, packaging, shipping conditions, lead time, and technical communication. These factors can influence reaction performance and the amount of incoming quality-control work required by your organization.

What Is 4-Pyrazoleboronic Acid Pinacol Ester?

4-Pyrazoleboronic acid pinacol ester is a protected boronic acid derivative containing a pyrazole ring and a cyclic pinacol boronate group. The pinacol ester form is generally selected because boronic acids can be sensitive to handling, moisture, and storage conditions, while protected boronate esters are convenient intermediates for synthetic planning. The pyrazole ring provides a nitrogen-containing heterocyclic scaffold that is frequently encountered in discovery and intermediate chemistry.

For product identification, buyers commonly reference the name 4-Pyrazoleboronic acid pinacol ester, CAS 269410-08-4, and the approximate molecular weight of 194.04 g/mol. I still advise confirming the exact structure, nomenclature, formula, and molecular weight on the supplier’s current specification sheet and SDS. Differences in naming conventions, tautomer descriptions, or database records should be resolved before material approval.

Core Uses and Application Scenarios

Suzuki–Miyaura Cross-Coupling

The principal value of this material is its use as a boron-containing coupling partner. In an appropriate reaction system, the pyrazole-derived boronate can participate in carbon–carbon bond formation with a suitable aryl, heteroaryl, or vinyl halide. The final outcome depends on the reaction substrate, catalyst, base, solvent, temperature, and work-up conditions, so I do not recommend treating the reagent as universally compatible with every coupling protocol.

Medicinal Chemistry and Discovery Libraries

Pyrazole-containing structures appear in many areas of medicinal chemistry because the ring can contribute useful hydrogen-bonding and electronic characteristics to a candidate molecule. This ester may therefore be selected when a project needs to introduce a pyrazole-linked aryl or heteroaryl fragment during analog synthesis. Its value is particularly relevant in parallel synthesis, scaffold exploration, and route scouting where several related compounds must be prepared efficiently.

Pharmaceutical Intermediate Development

For pharmaceutical intermediate projects, the material may be used during route development before a process team determines whether the same reagent is suitable for scale-up. At this stage, buyers should examine not only assay but also residual solvents, water content, elemental impurities, difficult-to-remove related substances, and lot-to-lot consistency. A material that performs well in a small reaction may still require additional qualification for a controlled manufacturing process.

Product Specifications to Review

Specifications should be matched to the intended use rather than selected from a generic catalog description. I suggest requesting a current technical data sheet, SDS, certificate of analysis, and representative analytical information before approval. The following table summarizes the fields that should be reviewed with the supplier.

Some buyers use a purity target of 98% or higher for research and intermediate work, but the correct acceptance limit depends on the reaction and internal quality system. I recommend requesting the actual batch result rather than relying only on a catalog statement. If the material will enter a regulated or highly sensitive process, ask whether additional analytical data can be supplied under a formal quotation.

How to Match the Product to Your Application

Step 1: Define the Reaction Requirement

Start by confirming whether the project needs a pyrazole boronate specifically, or whether another boronic ester could meet the same synthetic objective. Review the coupling partner, expected scale, catalyst system, and downstream purification strategy. This prevents a purchasing decision based only on a familiar product name.

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Step 2: Set the Quality Requirement

For early discovery work, a standard research-grade specification may be sufficient when the chemistry has a wide impurity tolerance. For process development, the buyer may need tighter controls over assay, water, residual solvents, metals, and related substances. I recommend documenting these requirements before requesting quotations so each supplier responds against the same criteria.

Step 3: Confirm Supply and Packaging

Ask whether the quoted material is available from existing stock, produced to order, or subject to a new manufacturing schedule. Packaging should be appropriate for the order quantity and protection requirements, with the container, label, batch information, and shipping arrangement clearly stated. For moisture-sensitive or air-sensitive handling concerns, request the supplier’s recommended storage and transport instructions rather than assuming a universal condition.

Step 4: Review the Pre-Shipment Documents

Before shipment, I suggest reviewing the COA, SDS, product specification, and commercial packing details. Confirm that the lot number on the documentation will correspond to the material being shipped. This simple check can reduce receiving delays and help your quality team decide whether additional incoming tests are required.

Pricing, MOQ, and Lead-Time Considerations

The price of CAS 269410-08-4 can vary according to order quantity, purity requirement, batch availability, packaging, analytical testing, and destination. A small research pack may have a higher price per gram than a development-scale order because the supplier must absorb packaging and handling costs over a smaller quantity. For this reason, I recommend requesting tiered pricing for at least three quantities when your project forecast is available.

Minimum order quantity is not always fixed across all suppliers. Stock material may be available in smaller quantities, while custom production or enhanced testing may require a higher MOQ. Lead time should also be separated into stock dispatch time, quality-release time, and manufacturing time; a quoted “lead time” without this distinction can create avoidable planning uncertainty.

When asking Maison Chemical for a quotation, provide the desired quantity, destination country, target specification, packaging preference, required documents, and expected delivery window. This allows me to assess the most suitable supply route rather than offering a generic catalog response. If your requirement is recurring, a rolling forecast may help with production and inventory planning, subject to confirmation.

Supplier Evaluation Checklist

• Can the supplier confirm CAS 269410-08-4 and provide a clear product identity?
• Is a batch-specific COA available for the offered lot?
• Are assay, impurity, water, and residual-solvent requirements clearly defined?
• Can the supplier explain whether the material is in stock or made to order?
• Are MOQ, packaging, lead time, and shipping terms stated in writing?
• Can the supplier support repeat orders with consistent documentation and communication?
• Does the supplier understand the difference between research use and process-development requirements?

At Maison Chemical, I approach this product as a B2B chemical supply project rather than a simple single-item transaction. Our support can include product identification review, quotation preparation, document coordination, packaging discussion, and export-order communication. Any specific specification, test, or delivery commitment should be confirmed in the quotation and supporting documents before purchase.

Common Buying Mistakes to Avoid

One common mistake is approving material based only on the CAS number while overlooking the actual assay method or impurity profile. Another is comparing prices without comparing quantity basis, packaging, analytical documentation, and delivery terms. Buyers should also avoid assuming that a reagent suitable for discovery chemistry automatically meets process or regulated-manufacturing requirements.

A further mistake is ordering too little for method development, repeat experiments, and incoming testing. Conversely, buying a large quantity before confirming reaction performance can create unnecessary inventory exposure. A practical approach is to qualify a representative batch at the intended application scale before establishing a larger supply plan.

Key Takeaways and Next Steps

4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 is a pyrazole-containing boronic ester used primarily as a synthetic building block, especially in suitable cross-coupling and medicinal chemistry routes. Its commonly associated molecular weight is approximately 194.04 g/mol, but buyers should verify identity and specifications against current supplier documentation. The best purchasing decision balances chemistry requirements, quality data, packaging, MOQ, lead time, and supplier responsiveness.

My recommended next step is to prepare a clear inquiry stating your required quantity, target purity, application, destination, documentation needs, and delivery schedule. Maison Chemical can then review the request and provide a product quotation based on the confirmed requirements. Contact us with your specification or forecast so we can help you evaluate a practical supply option for CAS 269410-08-4.

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