4-(N-Boc-amino)phenylboronic Acid CAS 380430-49-9 Supplier and Specification Guide
4-(N-Boc-amino)phenylboronic Acid CAS 380430-49-9 Supplier and Specification Guide
4-(N-Boc-amino)phenylboronic acid, also known as 4-(tert-butoxycarbonylamino)phenylboronic acid, is a protected aminophenyl boronic acid used mainly as a building block in medicinal chemistry, pharmaceutical intermediate development, and palladium-catalyzed cross-coupling research. The compound is identified by CAS No. 380430-49-9 and is commonly listed with the molecular formula C11H16BNO4 and a molecular weight of approximately 237.06 g/mol. As a supplier, I recommend confirming identity, assay, water content, residual solvents, packaging, and delivery requirements before placing a commercial order because available specifications can vary by grade and application.
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Maison Chemical supports buyers with product identification, specification review, sample coordination, commercial quotation, and shipment planning for this pharmaceutical intermediate. We do not treat a catalogue name alone as sufficient quality evidence; instead, we encourage customers to evaluate the analytical documentation and supply conditions relevant to their process.
Who This Guide Is For
This guide is intended for procurement teams, process chemists, medicinal chemistry groups, contract development and manufacturing organizations, and distributors sourcing 4-(N-Boc-amino)phenylboronic acid. It is particularly useful when a buyer needs to compare suppliers beyond headline price. The key questions are whether the material has the correct chemical identity, whether the purity is suitable for the intended reaction, and whether the supplier can provide consistent documentation and delivery support.
The guide can also help buyers prepare a clear request for quotation. A complete inquiry should state the required quantity, target assay, packaging preference, delivery destination, intended use, documentation requirements, and expected delivery window. Providing these details usually produces a more useful quotation than requesting a price without a defined specification.
Basic Product Identity and Chemical Context
Identification
| Item | Information |
|---|---|
| Product name | 4-(N-Boc-amino)phenylboronic acid |
| Alternative name | 4-(tert-butoxycarbonylamino)phenylboronic acid |
| CAS Number | 380430-49-9 |
| Reported molecular formula | C11H16BNO4 |
| Approximate molecular weight | 237.06 g/mol |
| Functional groups | Aryl boronic acid and Boc-protected aniline |
The molecule contains an aryl boronic acid group and a Boc-protected amino group. The boronic acid functionality is commonly used in Suzuki–Miyaura and related cross-coupling chemistry, while the Boc group can help protect the aniline nitrogen during selected synthetic operations. The actual suitability of the compound depends on the reaction sequence, catalyst system, solvent, temperature, work-up, and deprotection strategy used by the customer.
For independent identity checking, buyers can compare the supplier’s documentation with public chemical databases. PubChem provides compound records and identifiers for chemical substances, while the supplier’s certificate of analysis should remain the primary document for the specific batch being purchased. See the PubChem database for a public reference point; database records should not replace batch-specific testing.
How the Material Is Used
Cross-Coupling Building Block
In medicinal chemistry, 4-(N-Boc-amino)phenylboronic acid may be selected as a para-substituted aryl boronic acid for coupling with suitable aryl or heteroaryl halides. This can support the construction of biaryl or heteroaryl-aryl structures in discovery and process development. The Boc-protected amine is intended to reduce the likelihood of unwanted participation by the amino group during selected transformations, although protection behavior must be verified under the customer’s reaction conditions.
Intermediate Development
The compound may be evaluated in route development where a protected aniline and an aryl boronic acid are required in the same intermediate. It can be relevant to small-molecule pharmaceutical research, custom synthesis, and reference-standard preparation. It should not automatically be treated as a finished pharmaceutical ingredient, and buyers should define whether they require research grade, process-development grade, or another documented quality level.
Specification Requirements Buyers Should Review
A supplier specification should be reviewed against the intended reaction rather than selected only by the highest advertised purity. For many research applications, buyers may request an assay target such as 95.0%, 98.0%, or 99.0%, but the appropriate limit must be agreed with the project’s analytical and process teams. These percentages are procurement targets, not a claim that every Maison Chemical batch meets a particular value.
| Specification area | What to request | Why it matters |
|---|---|---|
| Identity | CAS number, molecular formula, molecular weight, and analytical identity data | Reduces the risk of ordering an isomer or incorrectly named material |
| Assay or purity | Defined method and acceptance limit, such as an HPLC area percentage | Helps relate material quality to reaction performance |
| Water content | Result and method, commonly reported in % or ppm | Boronic acids can be sensitive to handling and moisture-related variation |
| Residual solvents | Named solvents and limits in ppm where applicable | Supports process control and downstream compatibility |
| Appearance | Agreed description, such as color and physical form | Provides a basic incoming-material check |
| Packaging | Container type, net weight, and protective packing requirements | Helps preserve material condition during storage and transport |
Depending on the project, the buyer may also request NMR data, mass spectrometry, HPLC or GC information, elemental analysis, residual metals, and a safety data sheet. For a palladium-catalyzed process, residual metal expectations should be discussed before purchase rather than assumed from the product name. The European Chemicals Agency provides regulatory information through its official chemicals information resources, but regulatory obligations can differ according to jurisdiction, quantity, and intended use.
Material Options and Grade Considerations
Suppliers may offer different material options based on purity, batch size, packaging, and documentation depth. A small research pack may be appropriate for screening, while a larger pack may be needed for route development or repeated reaction campaigns. Buyers should distinguish between a stated catalogue purity and a fully agreed commercial specification with defined test methods and release criteria.
For early-stage chemistry, a standard research grade may be sufficient if the customer can confirm identity and purity internally. For process development, the buyer may need tighter controls for water, residual solvents, inorganic impurities, and trace metals. If the compound is used in a regulated development program, the customer should ask whether the supplier can support controlled change communication, batch traceability, and documentation suitable for the project.
Application Matching: Choosing the Right Specification
For Medicinal Chemistry Screening
Medicinal chemistry teams often prioritize availability, reliable identity, practical pack sizes, and rapid analytical confirmation. A target quantity of 1 g, 5 g, or 25 g may be sufficient for initial experiments, depending on the number of analogues planned. At this stage, the buyer should still request a batch certificate and confirm that the analytical data correspond to the supplied lot.
For Route and Process Development
Process teams generally need more than a single purity number. They may require a defined assay method, impurity profile, water result, residual-solvent information, and a realistic supply plan for quantities such as 100 g, 500 g, or 1 kg. Larger requirements should be discussed early because production scheduling, raw-material availability, and packaging controls can influence the final lead time.
For Custom or Regulated Projects
Where the material supports a regulated development program, the purchasing specification should be reviewed by procurement, quality, and technical stakeholders together. The team may need batch traceability, signed documentation, change-notification expectations, and a defined process for handling deviations. I recommend agreeing these requirements before commercial production rather than trying to add them after shipment.
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Supplier Selection Framework
A reliable supplier evaluation should cover four areas: technical fit, quality evidence, supply capability, and communication. Technical fit means that the supplier understands the requested CAS number, isomer, protection state, and intended use. Quality evidence means that the supplier can provide batch-specific documentation rather than only a generic product description.
- Confirm identity: Match the product name, CAS No. 380430-49-9, formula, molecular weight, and structure.
- Define the specification: Agree assay, impurity, water, residual-solvent, appearance, and packaging requirements.
- Request documentation: Ask for a certificate of analysis, safety data sheet, analytical data, and relevant traceability information.
- Check supply conditions: Confirm available quantity, MOQ, production status, estimated lead time, and shipping terms.
- Assess communication: Evaluate how clearly the supplier answers technical and commercial questions.
- Review a sample when appropriate: For an important route, test a representative sample before committing to a larger quantity.
Price should be compared on a like-for-like basis. A lower unit price may not represent lower total cost if the material requires additional testing, has a longer lead time, uses unsuitable packaging, or creates a higher risk of replacement. I recommend comparing the complete landed-cost and qualification picture, including freight, customs handling, analytical review, and potential schedule impact.
Pricing, MOQ, and Lead-Time Considerations
Pricing for 4-(N-Boc-amino)phenylboronic acid can vary with assay, pack size, batch availability, synthesis route, documentation, destination, and order frequency. A quotation for 1 g is not directly comparable with a quotation for 1 kg because packaging, testing, and production economics are different. Buyers should request a tiered quotation when they are considering multiple quantities.
MOQ is supplier- and project-dependent, so it should be confirmed in writing. Some orders may be fulfilled from available stock, while others may require production planning; an indicative window of 1–4 weeks should be treated only as a planning example, not a guaranteed delivery promise. Maison Chemical can review the required quantity and destination before confirming an estimated lead time, shipment arrangement, and commercial offer.
Storage and transport instructions should be taken from the current product label and safety data sheet. Buyers commonly ask whether the material should be protected from moisture, heat, light, or prolonged exposure to air, but the appropriate conditions must be confirmed for the specific batch and packaging configuration. Do not infer a shelf life, storage temperature, or retest period unless it is stated in controlled supplier documentation.
Common Purchasing Mistakes
Ordering by Name Alone
Similar names can refer to different substitution positions, protection groups, or boronic acid derivatives. The buyer should verify the structure and CAS number before approval. This is especially important when a project involves several aminophenylboronic acid isomers.
Requesting “High Purity” Without a Method
The phrase “high purity” is incomplete unless the analytical method and acceptance criteria are defined. HPLC area percentage, assay by another method, water content, and inorganic impurity limits can describe different quality dimensions. A clear specification prevents later disagreement between the purchaser and supplier.
Ignoring Moisture and Packaging
Boronic acid intermediates require suitable handling, and packaging can influence the condition of the material during storage and shipment. The buyer should request the proposed container, net quantity, sealing method, and handling instructions. If the project is moisture-sensitive, this requirement should appear in the purchase specification.
Planning Only for the First Batch
A single successful laboratory batch does not automatically establish long-term supply reliability. For recurring demand, buyers should discuss batch consistency, expected annual quantity, retest requirements, and change communication. A forecast can help the supplier plan raw materials and production capacity more effectively.
How Maison Chemical Supports Buyers
At Maison Chemical, I support inquiries by first confirming the exact product identity and intended specification. We can discuss target quantity, packaging, documentation, destination, and the difference between a sample request and a commercial supply requirement. Where the available information is not sufficient to make a firm claim, I prefer to mark it for confirmation rather than present an assumption as a guaranteed product fact.
Our support may include quotation preparation, sample coordination, certificate-of-analysis review, safety-document provision, shipment planning, and communication between the buyer’s technical team and the supply side. For larger or recurring requirements, I recommend sharing an estimated demand schedule so that availability and production planning can be assessed earlier. Final availability, MOQ, price, lead time, and specifications remain subject to written confirmation for the requested batch.
Buyer Checklist Before Issuing a Purchase Order
- Confirm the product is 4-(N-Boc-amino)phenylboronic acid, CAS 380430-49-9.
- Verify the molecular formula C11H16BNO4 and approximate molecular weight of 237.06 g/mol against the supplier documentation.
- Define the minimum assay or purity requirement and analytical method.
- Specify limits for water, residual solvents, trace metals, and key impurities where relevant.
- Request a batch-specific certificate of analysis and safety data sheet.
- Confirm package size, container type, labeling, and transport requirements.
- Ask for MOQ, stock status, estimated lead time, quotation validity, and delivery terms.
- Consider sample evaluation before a larger order for a critical synthetic route.
Summary Insight
4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 is a protected aminophenyl boronic acid building block used primarily in cross-coupling and pharmaceutical intermediate development. The most important purchasing controls are correct identity, a defined analytical specification, batch-specific documentation, suitable packaging, and a realistic supply plan. Buyers should compare suppliers on total technical and commercial value rather than unit price alone.
My recommended next step is to send Maison Chemical the required quantity, target purity, destination, packaging preference, documentation needs, and desired delivery date. We can then review the specification and provide a quotation based on the actual project requirements, subject to confirmation of batch availability and commercial conditions.
Contact Maison Chemical for a specification review, sample discussion, or quotation for 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9.
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