What Is 4-Butylphenylboronic Acid (CAS 145240-28-4)? Properties, Uses, and Buying Information

4-Butylphenylboronic acid, also called (4-butylphenyl)boronic acid, is an aryl boronic acid used primarily as a building block in organic synthesis. Its CAS Registry Number is 145240-28-4, its molecular formula is C₁₀H₁₅BO₂, and its calculated molecular weight is approximately 178.04 g/mol. The molecule contains one boronic acid group attached to a para-butyl-substituted benzene ring, making it relevant to palladium-catalyzed cross-coupling and related research applications.

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In practice, I recommend evaluating this material by identity, assay, water content, physical form, packaging, analytical documentation, and application fit rather than by the name alone. The exact appearance, purity, storage requirements, and delivery schedule should be confirmed against the supplier’s current specification and batch documentation. Maison Chemical can support qualified B2B buyers with product information, quotation review, packaging discussions, and sourcing coordination for this organic boronic acid.

What Is 4-Butylphenylboronic Acid?

4-Butylphenylboronic acid is an organoboron compound in which a boronic acid functionality, written as –B(OH)₂, is bonded to a phenyl ring. The butyl substituent is located at the 4-position, also known as the para position, relative to the boronic acid group. This structure combines a reactive boronic acid handle with a non-polar four-carbon alkyl substituent.

The compound has one boron atom and two oxygen atoms per molecule, while the hydrocarbon portion contains ten carbon atoms and fifteen hydrogen atoms. Its molecular weight of approximately 178.04 g/mol is useful for calculating molar quantities during reaction planning. Public chemical databases such as PubChem and CAS Common Chemistry should be used to cross-check identity information, while the supplier’s certificate of analysis should be used for batch-specific quality data.

Source: PubChem, National Center for Biotechnology Information, chemical structure and identifier resources: pubchem.ncbi.nlm.nih.gov; CAS Common Chemistry, Chemical Abstracts Service: commonchemistry.cas.org.

Core Properties and Chemical Functions

Structural and Identification Properties

The boronic acid group is the principal reactive site used in many synthetic transformations. The para-butyl group can influence the compound’s hydrophobicity, steric environment, and compatibility with the surrounding molecular design. However, these structural effects do not by themselves guarantee a particular reaction yield, solubility profile, or process performance.

Physical Properties That Require Verification

Commercial product information may describe 4-butylphenylboronic acid as a solid, but the exact color, particle form, melting behavior, water content, and stability should be confirmed from the current technical data sheet. I do not recommend using an unverified melting point or appearance description as a release criterion. For production or regulated development, the batch certificate of analysis should take priority over a general catalog entry.

Solubility is also application-dependent because it can vary with solvent, concentration, temperature, water content, and the presence of bases or other reagents. A buyer should request solvent-specific information when the material will be used in a concentrated reaction, automated synthesis platform, or formulation-like screening system. If no validated solubility data are available, a small compatibility test is a more reliable approach than assuming complete dissolution.

What Are the Main Uses of 4-Butylphenylboronic Acid?

Suzuki–Miyaura Cross-Coupling

The most relevant use is as an aryl boronic acid coupling partner in Suzuki–Miyaura reactions. In a typical reaction design, the boronic acid component reacts with an aryl or heteroaryl halide or a related electrophile in the presence of a suitable palladium catalyst and base. The transformation forms a new carbon–carbon bond and transfers the 4-butylphenyl group into the target molecule.

Actual performance depends on the electrophile, catalyst system, ligand, base, solvent, temperature, concentration, and work-up method. As an initial laboratory screening range, chemists may compare approximately 1.0–1.5 equivalents of the boronic acid and reaction concentrations around 0.05–0.20 mol/L, but these are development starting points rather than product specifications. Reaction optimization should be performed using the buyer’s own substrate and analytical method.

Source: Miyaura, N. and Suzuki, A., “Stereoselective synthesis of arylated alkenes via the cross-coupling reaction of alkenylboranes with aryl halides,” Journal of the American Chemical Society, 1979, which established the foundational boron-based cross-coupling chemistry associated with the Suzuki reaction.

Medicinal and Discovery Chemistry

In medicinal chemistry, 4-butylphenylboronic acid may be selected to introduce a lipophilic aryl fragment into a small molecule during analogue synthesis. The butyl substituent can be useful when a research team is exploring hydrophobic substituent changes across a compound series. Its suitability must still be assessed in the context of the target scaffold, biological objective, downstream purification, and final compound profile.

Research teams may also use this compound in parallel synthesis, route scouting, and structure–activity relationship programs. The material is generally more valuable as a defined synthetic intermediate than as a finished active ingredient. I recommend confirming whether the intended use requires research-grade material, higher-purity material, or a documented quality package suitable for process development.

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Process Development and Custom Synthesis

Process chemists may evaluate this building block when developing a route that requires a para-butyl-substituted biaryl or related aromatic structure. At larger scale, factors such as filtration behavior, impurity carryover, residual solvents, catalyst removal, and waste treatment can become as important as reaction conversion. A laboratory result should therefore not be treated as proof of manufacturing suitability without additional scale-up assessment.

Types, Grades, and Material Options

Buyers will usually encounter this compound as a research or synthesis-grade organic intermediate, although naming conventions vary among suppliers. Some suppliers may offer a standard catalog pack, while others may arrange larger quantities or production-oriented sourcing after reviewing the technical requirement. The available grade should be judged by its analytical specification and intended application, not by the grade label alone.

For most B2B evaluations, I suggest separating identity requirements from performance requirements. Identity requirements may include CAS number, formula, molecular weight, NMR or other analytical confirmation, and assay. Performance requirements may include water content, residual solvents, particle characteristics, and reaction-specific impurity limits.

Key Specifications to Request Before Buying

A useful specification package should identify the material unambiguously and define how quality is measured. At minimum, I recommend requesting the product name, CAS number 145240-28-4, molecular formula, molecular weight, assay method, appearance, storage guidance, packaging information, and certificate of analysis availability. If the compound will enter a controlled development process, the buyer should also discuss traceability and change-notification expectations.

• Identity: Confirm the name, CAS number, molecular formula, and analytical identity.
• Assay: Request the test method, reporting basis, and acceptance limit rather than relying only on a headline purity number.
• Water content: Ask whether water is measured and whether the result is reported for each batch.
• Residual solvents: Confirm whether solvent residues are controlled and documented.
• Physical form: Verify powder, crystalline, or other supplied form when feeding or weighing equipment is involved.
• Packaging: Match the pack size and inner packaging to the expected consumption rate and handling environment.
• Documents: Request the SDS, technical data sheet, certificate of analysis, and shipping documents where applicable.

For a development project, a buyer may also define a practical sample quantity such as 1–10 g for initial screening, followed by a larger quantity after route confirmation. These quantities are purchasing examples, not fixed market standards. The appropriate MOQ depends on supplier inventory, production economics, packaging, and the buyer’s forecasted demand.

How to Select a Supplier

Evaluate Technical Fit First

I recommend sending suppliers a concise technical inquiry that includes the CAS number, target quantity, required assay, intended use, delivery destination, and documentation requirements. If the application is sensitive to water or trace impurities, state those requirements before receiving a quotation. This allows suppliers to distinguish a simple catalog request from a process-development or recurring-supply opportunity.

Price should be compared together with assay basis, net weight, packaging, shipping terms, lead time, and documentation. A lower quoted unit price may not represent lower total cost if the pack size, testing package, or delivery schedule does not match the project. For international procurement, the buyer should also review import classification, hazardous-goods handling, and local compliance requirements with the relevant logistics and regulatory teams.

Maison Chemical Supplier Support

At Maison Chemical, I approach 4-butylphenylboronic acid inquiries by first clarifying the customer’s identity and quality requirements. I can help organize product specifications, batch documentation requests, sample or quantity discussions, packaging preferences, and delivery planning. Where a requirement is not covered by standard information, I recommend confirming it in writing before the purchase order is issued.

For recurring B2B demand, I also recommend reviewing forecast volumes, acceptable batch-to-batch variation, retest expectations, and change-control communication. These points can reduce avoidable delays when a research quantity becomes a development or production requirement. Any final availability, MOQ, price, lead time, and specification should be confirmed through a current Maison Chemical quotation.

Buyer Checklist for 4-Butylphenylboronic Acid

1. Confirm that the requested material is 4-butylphenylboronic acid with CAS 145240-28-4.
2. Check that the stated molecular formula is C₁₀H₁₅BO₂ and the approximate molecular weight is 178.04 g/mol.
3. Define the required assay and analytical method before comparing quotations.
4. Ask for batch-specific documentation, including a certificate of analysis and safety data sheet.
5. Clarify water, residual solvent, appearance, and packaging requirements where relevant.
6. Confirm whether the order is for a small research pack, development quantity, or recurring supply.
7. Review lead time, MOQ, shipping terms, and import responsibilities before placing the order.
8. Use a small application test to verify solubility and reaction suitability in the buyer’s own process.

Key Takeaways

• 4-Butylphenylboronic acid is an aryl boronic acid identified by CAS 145240-28-4.
• Its molecular formula is C₁₀H₁₅BO₂, with an approximate molecular weight of 178.04 g/mol.
• Its principal role is as a synthetic building block, especially for Suzuki–Miyaura carbon–carbon coupling.
• The compound’s exact assay, appearance, water content, solubility, and storage requirements must be verified from current batch documentation.
• Buyers should compare technical specifications, documents, MOQ, lead time, packaging, and total delivered cost—not unit price alone.

Conclusion: Is 4-Butylphenylboronic Acid Right for Your Project?

4-Butylphenylboronic acid is a practical building block when a synthesis requires a para-butylphenyl fragment and a boronic acid coupling handle. Its verified identity is CAS 145240-28-4, with formula C₁₀H₁₅BO₂ and approximate molecular weight 178.04 g/mol. Its most established application area is organic synthesis, particularly research and development involving boron-mediated cross-coupling.

My recommended next step is to prepare a purchase specification covering quantity, assay, analytical documents, packaging, delivery location, and intended use. Send these requirements to Maison Chemical for a current quotation and technical review. Before scale-up, confirm the material in your own reaction system and align batch documentation with your internal quality procedures.

For a 4-Butylphenylboronic acid sourcing inquiry, contact Maison Chemical with your required quantity, specification, packaging, destination, and target delivery schedule.

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